Description

3-Fluoro-5-Methylphenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern cross-coupling reactions. Its value lies in providing a stable, air- and moisture-tolerant reagent for the efficient synthesis of complex biaryl structures, a cornerstone of pharmaceutical and agrochemical discovery. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel molecular scaffolds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for the synthesis of fluorinated and methyl-substituted biaryl compounds, which are prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Serves as a precursor for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and organometallic chemistry research.
• Material Science Research: Used to synthesize organic semiconductors, liquid crystals, and other functional organic materials requiring precise fluorinated aromatic structures.
• Chemical Biology Probes: Facilitates the creation of tagged molecules for studying biological processes and protein interactions.

Basic Information

Product Name	3-Fluoro-5-Methylphenylboronic Acid Pinacol Ester
CAS No.	1583286-47-8
Molecular Formula	C₁₃H₁₈BFO₂
Molecular Weight	236.09 g/mol
Synonyms	3-Fluoro-5-methylbenzeneboronic acid pinacol ester; (3-Fluoro-5-methylphenyl)boronic acid pinacol ester; 2-(3-Fluoro-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Fluoro-5-methylphenyl-Bpin; B-(3-Fluoro-5-methylphenyl)pinacolborane; 5-Methyl-3-fluorophenylboronic acid pinacol ester; 1583286-47-8
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-5-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality commitment includes comprehensive analysis via NMR, HPLC, and GC to verify identity, purity, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.