Description

3-(4-Fluoro-Tetrahydro-2H-Pyran-4-Yl)Benzoic Acid is a high-purity fluorinated organic building block of significant interest in advanced chemical synthesis. Its unique structure, featuring a fluorinated tetrahydropyran ring fused to a benzoic acid moiety, makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for drug discovery and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atom and heterocyclic structure can enhance biological activity and environmental stability.
• Material Science Precursor: Acts as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical space and improve pharmacokinetic properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale cGMP batches for clinical trials.

Basic Information

Product Name	3-(4-Fluoro-Tetrahydro-2H-Pyran-4-Yl)Benzoic Acid
CAS No.	1556049-81-0
Molecular Formula	C12H13FO3
Molecular Weight	224.23 g/mol
Synonyms	3-(4-Fluorooxan-4-yl)benzoic acid; 4-Fluoro-4-(3-carboxyphenyl)tetrahydro-2H-pyran; Benzoic acid, 3-(4-fluoro-4-tetrahydro-2H-pyranyl)-; 1556049-81-0; 3-(4-Fluoro-tetrahydro-pyran-4-yl)-benzoic acid; 3-(4-Fluorotetrahydropyran-4-yl)benzoic acid; 4-(3-Carboxyphenyl)-4-fluorotetrahydropyran
EINECS	Contact for details

Quality Control

Our 3-(4-Fluoro-Tetrahydro-2H-Pyran-4-Yl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.