Description

Methyl 2-Bromo-3-Chloro-5-Fluorobenzoate is a high-purity, multi-halogenated benzoate ester, a crucial building block in advanced organic synthesis. Its precise halogen substitution pattern makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogenated aromatic core provides bioactivity.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands and organometallic catalysts used in cross-coupling and other metal-mediated reactions.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers requiring halogenated aromatic monomers.
• Custom Synthesis and Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) serving clients in life sciences.
• Academic and Industrial R&D: Utilized in research laboratories for method development and exploring new chemical spaces in heterocyclic and fluorinated chemistry.

Basic Information

Item	Details
Product Name	Methyl 2-Bromo-3-Chloro-5-Fluorobenzoate
CAS No.	1537548-66-5
Molecular Formula	C8H5BrClFO2
Molecular Weight	267.48 g/mol
Synonyms	2-Bromo-3-chloro-5-fluorobenzoic acid methyl ester; Methyl 2-bromo-3-chloro-5-fluorobenzoate; Benzoic acid, 2-bromo-3-chloro-5-fluoro-, methyl ester; Methyl 2-bromo-3-chloro-5-fluorobenzoate; 1537548-66-5; Methyl ester of 2-bromo-3-chloro-5-fluorobenzoic acid
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Bromo-3-Chloro-5-Fluorobenzoate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality system is designed to meet the rigorous demands of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.