Description

4,5-Difluoro-1-Benzofuran-2-Carboxylic Acid is a high-value fluorinated benzofuran derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its unique difluorinated aromatic structure, which is instrumental for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a starting material for synthesizing specialized fluorinated polymers, liquid crystals, or organic electronic materials.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes and tags for studying biological systems and mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	4,5-Difluoro-1-Benzofuran-2-Carboxylic Acid
CAS No.	1521284-52-5
Molecular Formula	C9H4F2O3
Molecular Weight	198.13 g/mol
Synonyms	4,5-Difluorobenzofuran-2-carboxylic acid; 2-Benzofurancarboxylic acid, 4,5-difluoro-; 4,5-Difluoro-2-benzofurancarboxylic acid; 4,5-Difluoro-1-benzofuran-2-carboxylate; 1521284-52-5; 4,5-Difluorobenzo[b]furan-2-carboxylic acid; Difluorobenzofuran carboxylic acid
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-1-Benzofuran-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.