Description

4-Chloro-2-Fluoro-5-Iodo-Benzoic Acid Methyl Ester is a high-purity, multi-halogenated aromatic building block of significant value in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules, particularly in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on novel active ingredients, where its reactive sites enable precise structural modifications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting new therapeutic agents.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and advanced organic materials.
• Ligand Synthesis: Employed in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized as a scaffold for creating molecular probes and diagnostic agents due to the presence of iodine for potential radiolabeling.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse biaryl structures.

Basic Information

Product Name	4-Chloro-2-Fluoro-5-Iodo-Benzoic Acid Methyl Ester
CAS No.	1516210-03-9
Molecular Formula	C8H5ClFIO2
Molecular Weight	314.48 g/mol
Synonyms	Methyl 4-Chloro-2-fluoro-5-iodobenzoate; Benzoic acid, 4-chloro-2-fluoro-5-iodo-, methyl ester; 4-Chloro-2-fluoro-5-iodobenzoic acid methyl ester; Methyl 4-chloro-2-fluoro-5-iodobenzoate; 1516210-03-9; 4-Chloro-2-fluoro-5-iodo-benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-5-Iodo-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications in GMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.