Description

3,3-Difluoro-3-Phenylpropanoic Acid is a high-value fluorinated building block characterized by a phenyl ring and a difluorinated propanoic acid chain. This compound matters for its role in introducing the difluoromethylene (CF2) group into target molecules, a modification known to enhance metabolic stability, lipophilicity, and bioavailability in active pharmaceutical ingredients. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel drug candidates and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms can improve compound activity and environmental persistence.
• Fluorine Chemistry Research: Serves as a versatile starting material in academic and industrial R&D for exploring new fluorination methodologies and creating novel fluorinated compounds.
• Liquid Crystal & Material Science: Employed in the synthesis of fluorinated organic materials, including potential precursors for liquid crystal displays (LCDs) and specialty polymers.
• Peptide Mimetics: The carboxylic acid functionality allows for incorporation into peptide chains to create fluorinated analogs with modified biological properties.
• Cross-Coupling Reactions: The aromatic ring makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to build more complex molecular architectures.

Basic Information

Product Name	3,3-Difluoro-3-Phenylpropanoic Acid
CAS No.	1507967-83-0
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	3,3-Difluoro-3-phenylpropionic acid; 3-Phenyl-3,3-difluoropropanoic acid; β,β-Difluoro-β-phenylpropionic acid; 3,3-Difluoro-3-phenylpropanoate; DFPPA; 1507967-83-0; 3,3-Difluoro-3-phenylpropanoic acid (DFPPA)
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-3-Phenylpropanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.