Description

Ledipasvir Diacetone CAS NO 1502655-48-2 is a key pharmaceutical intermediate, specifically a protected form of the active pharmaceutical ingredient Ledipasvir. This compound is of critical importance in the synthesis of modern antiviral medications. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in the development and production of treatments for hepatitis C virus (HCV) infection.

Application

• Primary Intermediate in the synthesis of Ledipasvir, a direct-acting antiviral (DAA) agent.
• Active Pharmaceutical Ingredient (API) Manufacturing for HCV combination therapies.
• Pharmaceutical Research & Development for novel antiviral drug candidates.
• Process Chemistry & Scale-Up studies in contract development and manufacturing organizations (CDMOs).
• Reference Standard for quality control and analytical method development in pharmaceutical labs.
• Academic Research in virology and medicinal chemistry programs.

Basic Information

Product Name	Ledipasvir Diacetone
CAS No.	1502655-48-2
Molecular Formula	C56H66F2N8O8
Molecular Weight	993.18 g/mol
Synonyms	Ledipasvir Diacetone; Ledipasvir Acetone Adduct; GS-5885 Acetone Adduct; (2R,5S,13aR)-8-Methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid, 1,1-dimethylethyl ester, compound with acetone (1:2); Ledipasvir Acetone Solvate; GS-5885 Diacetone Solvate
EINECS	Contact for details

Quality Control

Our Ledipasvir Diacetone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by spectroscopic methods (IR, NMR), and control of residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.