Description

3,5-Difluoro-4-(Trifluoromethyl)Phenyl Boronic Acid is a high-value, multi-fluorinated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both difluoro and trifluoromethyl substituents, makes it an essential reagent for introducing lipophilic and electron-withdrawing motifs into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity, stability, and membrane permeability.
• Material Science: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic systems improve charge transport and environmental stability.
• Suzuki-Miyaura Cross-Coupling: A versatile boronic acid partner for palladium-catalyzed C-C bond formation, enabling the construction of complex, fluorinated biaryl structures.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Life Science Research: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new chemical entities.

Basic Information

Product Name	3,5-Difluoro-4-(Trifluoromethyl)Phenyl Boronic Acid
CAS No.	1459778-94-9
Molecular Formula	C7H4BF5O2
Molecular Weight	225.91 g/mol
Synonyms	[3,5-Difluoro-4-(trifluoromethyl)phenyl]boronic acid; (3,5-Difluoro-4-(trifluoromethyl)phenyl)boronic acid; 4-(Trifluoromethyl)-3,5-difluorophenylboronic acid; Boronic acid, B-[3,5-difluoro-4-(trifluoromethyl)phenyl]-; 3,5-Difluoro-4-trifluoromethylbenzeneboronic acid; 3,5-Difluoro-alpha,alpha,α-trifluoro-p-tolylboronic acid; CAS 1459778-94-9
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-(Trifluoromethyl)Phenyl Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance for sensitive cross-coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.