Description

Paritaprevir Dihydrate is a high-purity active pharmaceutical ingredient (API) and a key component of direct-acting antiviral (DAA) combination therapies. Its primary value lies in its targeted mechanism of action against the hepatitis C virus (HCV), specifically as an NS3/4A protease inhibitor, offering a critical tool in modern antiviral treatment regimens. This compound is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of advanced antiviral medications, particularly for combating HCV genotypes 1 and 4. Consistent quality and reliable supply are paramount for ensuring the efficacy and safety of the final drug product.

Application

• Active Pharmaceutical Ingredient (API) in fixed-dose combination therapies for Hepatitis C Virus (HCV) infection.
• Pharmaceutical Research & Development for novel antiviral drug formulations and combination studies.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research focusing on the NS3/4A protease enzyme mechanism and viral replication inhibition.
• Manufacturing of Finished Dosage Forms such as tablets and capsules in GMP-certified facilities.

Basic Information

Product Name	Paritaprevir Dihydrate
CAS No.	1456607-71-8
Molecular Formula	C40H43N7O7S · 2H2O
Molecular Weight	777.89 g/mol (as dihydrate)
Synonyms	Paritaprevir; ABT-450; ABT450; (2R,6S,12Z,13aS,14aR,16aS)-N-(Cyclopropylsulfonyl)-6-{[(5-methyl-2-pyrazinyl)carbonyl]amino}-5,16-dioxo-2-{6-(phenoxy)pyridin-3-yl}-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide Dihydrate; ABT-450 Dihydrate
EINECS	Contact for details

Quality Control

Our Paritaprevir Dihydrate is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical actives. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS. A Certificate of Analysis (COA) detailing all test results against predefined specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. The original container should be kept sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	4.0% - 6.0%
Related Substances (HPLC)	Individual impurity: ≤0.5% Total impurities: ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.