Description

4-Fluoro-3-(Methylthio)Phenylboronic Acid is a high-purity organoboron building block essential for modern synthetic chemistry. This compound matters for its role as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: Critical for synthesizing novel drug candidates, particularly in constructing fluorinated and sulfur-containing aromatic scaffolds for oncology and CNS therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the fluorine and methylthio groups contribute to biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and material science applications.
• OLED & Electronic Material Research: Employed in the synthesis of advanced organic semiconductors and light-emitting materials for display technologies.
• Chemical Biology & Probe Development: Utilized in creating molecular probes and tags for studying biological processes and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses serving the pharmaceutical and biotechnology industries.

Basic Information

Product Name	4-Fluoro-3-(Methylthio)Phenylboronic Acid
CAS No.	1451392-39-4
Molecular Formula	C7H8BFO2S
Molecular Weight	185.99 g/mol
Synonyms	4-Fluoro-3-(methylthio)benzeneboronic acid; (4-Fluoro-3-methylsulfanylphenyl)boronic acid; 3-Methylthio-4-fluorophenylboronic acid; B-[4-Fluoro-3-(methylthio)phenyl]boronic acid; 4-Fluoro-3-methylmercaptophenylboronic acid; 4-Fluoro-3-(methylsulfanyl)phenylboronic acid; CAS 1451392-39-4
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(Methylthio)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment supports applications in GMP-intermediate manufacturing and other regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere such as nitrogen or argon. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.