Description

3,5-Difluoro-4-(Methylthio)Phenylboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound matters for its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used to construct novel herbicide and fungicide candidates with enhanced efficacy and environmental profiles.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and asymmetric synthesis.
• Chemical Biology Probes: Utilized to synthesize molecular probes for studying biological pathways and protein functions.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	3,5-Difluoro-4-(Methylthio)Phenylboronic Acid
CAS No.	1451392-38-3
Molecular Formula	C7H7BF2O2S
Molecular Weight	203.99 g/mol
Synonyms	4-(Methylthio)-3,5-difluorophenylboronic Acid; (3,5-Difluoro-4-(methylthio)phenyl)boronic Acid; 3,5-Difluoro-4-methylsulfanylbenzeneboronic Acid; B-[3,5-Difluoro-4-(methylthio)phenyl]boronic Acid; 1451392-38-3; 3,5-Difluoro-4-methylmercaptophenylboronic Acid
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-(Methylthio)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient moisture. Recommended storage temperature is 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.