Description

3-(N,o-Dimethylhydroxylaminocarbonyl)-5-Fluorophenylboronic Acid is a specialized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a protected hydroxylamine moiety, enabling the synthesis of complex heterocyclic and pharmaceutical intermediates. This high-purity reagent is essential for researchers and process chemists in pharmaceutical development, agrochemical research, and advanced material science, where precise molecular construction is paramount.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems and heterocycles.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for constructing biaryl and complex conjugated molecular architectures.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides that require fluorinated phenylboronic acid components.
• Material Science: Building block for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Potential use in developing activity-based probes and affinity reagents due to its reactive handles.
• Academic & R&D: Fundamental reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	3-(N,o-Dimethylhydroxylaminocarbonyl)-5-Fluorophenylboronic Acid
CAS No.	1451392-31-6
Molecular Formula	C9H11BFNO4
Molecular Weight	226.99 g/mol
Synonyms	[3-[(Dimethylamino)oxomethyl]-5-fluorophenyl]boronic Acid; 5-Fluoro-3-[(N,o-dimethylhydroxylamino)carbonyl]benzeneboronic Acid; 3-(N,O-Dimethylhydroxycarbamoyl)-5-fluorobenzeneboronic Acid; (3-((Dimethylamino)carbonyl)-5-fluorophenyl)boronic Acid (tautomeric form); Boronic Acid, B-[3-[(dimethylamino)carbonyl]-5-fluorophenyl]-; CAS 1451392-31-6; DMHF-BA (abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 3-(N,o-Dimethylhydroxylaminocarbonyl)-5-Fluorophenylboronic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment, supporting cGMP and ISO 9001 standards for traceability and reliability in critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by titration)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.