Description

3-Chloro-5-Fluoro-4-Methoxyphenylboronic Acid is a high-purity, multi-functional boronic acid derivative essential for modern synthetic chemistry. Its value lies in its role as a key building block for constructing complex molecular architectures via cross-coupling reactions. This compound is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organometallic catalysts.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: Utilized to create boronic acid-based probes for sensing and protein interaction studies.
• Custom Synthesis & Contract Manufacturing: A vital raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	3-Chloro-5-Fluoro-4-Methoxyphenylboronic Acid
CAS No.	1451392-04-3
Molecular Formula	C7H7BClFO3
Molecular Weight	203.39 g/mol
Synonyms	(3-Chloro-5-fluoro-4-methoxyphenyl)boronic acid; 3-Chloro-5-fluoro-4-methoxybenzeneboronic acid; 4-Methoxy-3-chloro-5-fluorophenylboronic acid; Boronic acid, B-(3-chloro-5-fluoro-4-methoxyphenyl)-; 1451392-04-3; 3-Chloro-5-fluoro-4-methoxy-phenylboronic acid; (3-Chloro-5-fluoro-4-methoxyphenyl)boronic acid pinacol ester (common derivative).
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluoro-4-Methoxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent oxidation and hydrolysis. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.