Description

4-Bromo-3-Ethoxycarbonyl-2-Fuorophenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its molecular structure, featuring bromo, fluoro, and ester functionalities adjacent to the boronic acid group, makes it an exceptionally versatile reagent for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly through Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or building block for creating advanced organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of novel bidentate ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	4-Bromo-3-Ethoxycarbonyl-2-Fuorophenylboronic Acid
CAS No.	1451391-94-8
Molecular Formula	C9H7BBrFO4
Molecular Weight	288.87 g/mol
Synonyms	(4-Bromo-3-(ethoxycarbonyl)-2-fluorophenyl)boronic acid; 2-Fluoro-4-bromo-3-ethoxycarbonylbenzeneboronic acid; 4-Bromo-2-fluoro-3-(ethoxycarbonyl)phenylboronic acid; Boronic acid, B-[4-bromo-3-(ethoxycarbonyl)-2-fluorophenyl]-; 4-Bromo-3-carbethoxy-2-fluorophenylboronic acid; Ethyl 5-borono-6-fluoro-2-bromobenzoate
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-3-Ethoxycarbonyl-2-Fuorophenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions and regulatory filings. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity (typically ≥95% by HPLC), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage or when opening a new container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.