Description

2-Diphenylphosphino-2',6'-Bis(Dimethylamino)-1,1'-Biphenyl is a sophisticated, electron-rich phosphine ligand designed for advanced catalytic applications. This compound matters because it enables highly efficient and selective cross-coupling reactions, which are critical for synthesizing complex organic molecules. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and specialty chemicals.

Application

• As a highly active ligand in palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig amination).
• For the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs) requiring challenging C-N or C-C bond formations.
• In the development of agrochemicals and fine chemicals where high selectivity and yield are paramount.
• As a catalyst component in materials science for creating conjugated polymers or organic electronic materials.
• For academic and industrial research into new catalytic methodologies and reaction optimization.
• In scale-up process development for transitioning laboratory-scale reactions to pilot and production scale.

Basic Information

Product Name	2-Diphenylphosphino-2',6'-Bis(Dimethylamino)-1,1'-Biphenyl
CAS No.	1447963-71-4
Molecular Formula	C28H30N2P
Molecular Weight	425.53 g/mol
Synonyms	2-(Diphenylphosphino)-2',6'-bis(dimethylamino)-1,1'-biphenyl; BrettPhos Ligand; BrettPhos; t-BuBrettPhos Precursor; 2'-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamine (common mis-assignment); Biarylphosphine ligand; Buchwald ligand; XPhos-type ligand.
EINECS	Contact for details

Quality Control

Every batch of our 2-Diphenylphosphino-2',6'-Bis(Dimethylamino)-1,1'-Biphenyl undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive catalytic applications. Our quality management system ensures traceability and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to minimize oxidation and prolong shelf-life. Allow the container to reach room temperature in a dry environment before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.