Description

3-Amino-2-Bromo-6-Fluoro-Benzoic Acid Methyl Ester is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. Its unique halogenated and aminated structure makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by pharmaceutical R&D and agrochemical manufacturers for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Serves as a building block for novel herbicides, fungicides, and insecticides, leveraging the fluorine and bromine atoms for enhanced bioactivity and environmental stability.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its conjugated aromatic system.
• Dye and Pigment Manufacturing: Intermediate for creating advanced colorants and fluorescent markers with specific light-absorption properties.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for introducing complex aromatic fragments.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and process development projects.

Basic Information

Product Name	3-Amino-2-Bromo-6-Fluoro-Benzoic Acid Methyl Ester
CAS No.	1446261-65-9
Molecular Formula	C8H7BrFNO2
Molecular Weight	248.05 g/mol
Synonyms	Methyl 3-Amino-2-Bromo-6-Fluorobenzoate; 2-Bromo-6-Fluoro-3-Aminobenzoic Acid Methyl Ester; Benzoic acid, 3-amino-2-bromo-6-fluoro-, methyl ester; 3-Amino-2-bromo-6-fluorobenzoic acid methyl ester; Methyl 3-amino-2-bromo-6-fluorobenzoate; 1446261-65-9
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-2-Bromo-6-Fluoro-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive synthesis applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.