Description

5-Bromo-3-Carboxy-2-Methoxybenzotrifluoride, also known as 5-Bromo-3-(Trifluoromethyl)-o-Anisic Acid, is a high-value trifluoromethylated aromatic building block. This compound is essential for introducing both bromine and carboxylic acid functional groups into complex molecular architectures, enabling precise structural modifications. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and polymers requiring specific halogenated and fluorinated motifs.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	5-Bromo-3-Carboxy-2-Methoxybenzotrifluoride
CAS No.	1445995-86-7
Molecular Formula	C10H6BrF3O3
Molecular Weight	311.05 g/mol
Synonyms	5-Bromo-3-(trifluoromethyl)-o-anisic acid; 2-Methoxy-5-bromo-3-(trifluoromethyl)benzoic acid; 5-Bromo-2-methoxy-3-(trifluoromethyl)benzoic acid; 3-Carboxy-5-bromo-2-methoxybenzotrifluoride; Benzoic acid, 5-bromo-2-methoxy-3-(trifluoromethyl)-; 5-Bromo-3-(trifluoromethyl)-2-methoxybenzoic acid
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-3-Carboxy-2-Methoxybenzotrifluoride adheres to stringent quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each shipment, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.