Description

Ledipasvir (Acetone) is a high-purity chemical intermediate of significant importance in modern pharmaceutical synthesis. Its primary value lies in its role as a key building block for the production of Ledipasvir, a critical active pharmaceutical ingredient (API) used in antiviral therapies. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development and scale-up of hepatitis C treatments and related antiviral compounds.

Application

• Pharmaceutical Intermediate: Primary use as a crucial synthetic precursor in the multi-step synthesis of the antiviral drug Ledipasvir.
• API (Active Pharmaceutical Ingredient) Manufacturing: Serves as a key raw material in Good Manufacturing Practice (GMP) production processes for final drug substance.
• Research & Development: Utilized in medicinal chemistry and process chemistry research for developing new antiviral compounds and optimizing synthetic routes.
• Process Scale-Up: Critical for pilot plant and commercial-scale manufacturing, ensuring consistent quality and supply for drug production.
• Reference Standard: Can be used in analytical laboratories for method development and quality control testing of related substances.

Basic Information

Product Name	Ledipasvir (Acetone)
CAS No.	1441674-54-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Ledipasvir Acetone Solvate; Ledipasvir Acetone Adduct; GS-5885 Acetone Solvate; (6S)-6-Deoxy-6-{4-[4-(9,9-Difluoro-7-{2-[(1R,3S,4S)-2-[(2S)-2-{(Methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]phenyl}amino}cyclohexyl 5-O-{(2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl}methyl Hydrogen Phosphonate Acetone Solvate
EINECS	Contact for details

Quality Control

Our Ledipasvir (Acetone) is produced under strict quality management systems to ensure it meets the exacting standards required for pharmaceutical intermediates. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling using advanced techniques such as HPLC and NMR. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.