Description

Leukotriene C4-D5 is a stable isotope-labeled analog of the cysteinyl leukotriene C4 (LTC4), specifically deuterated at five positions. This compound serves as a critical internal standard for the precise quantification of endogenous LTC4 in complex biological matrices via mass spectrometry. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and biotechnology sectors, enabling accurate pharmacokinetic studies, biomarker validation, and drug development research focused on inflammation and allergic responses.

Application

• Mass Spectrometry Internal Standard: Primary use as a deuterated internal standard for the accurate quantification of Leukotriene C4 in LC-MS/MS and GC-MS assays.
• Biomarker Research: Essential for validating LTC4 as a biomarker in studies of asthma, allergic rhinitis, and other inflammatory diseases.
• Drug Metabolism & Pharmacokinetics (DMPK): Used to track the metabolism and clearance of leukotriene pathway modulators in preclinical and clinical studies.
• In Vitro Diagnostic (IVD) Development: A key component in calibrators and controls for diagnostic kits measuring eicosanoid levels.
• Academic & Basic Research: Fundamental tool for investigating the role of cysteinyl leukotrienes in cellular signaling and pathophysiology.
• Quality Control in Pharmaceutical Manufacturing: Employed in analytical methods to ensure the purity and consistency of related pharmaceutical compounds.

Basic Information

Product Name	Leukotriene C4-D5
CAS No.	1441421-73-3
Molecular Formula	C30H42D5N3O9S
Molecular Weight	~629.8 g/mol
Synonyms	LTC4-d5; Leukotriene C4 (5,6,8,9,11-d5); (5S,6R)-6-[(2R)-2-[(4E,7E,9E,11Z,14Z)-5-[(1R,2E,4E,6Z,9Z)-1-[(2S)-2-Amino-2-carboxyethyl]sulfanyl-2-hydroxy-4,6,9-pentadecatrien-1-ylidene]tetrahydro-2H-pyran-2-ylidene]ethoxy]-5-hydroxyicosa-7,9,11,14-tetraenoic acid-d5; Deuterated LTC4; Cysteinyl Leukotriene C4-d5
EINECS	Contact for details

Quality Control

Our Leukotriene C4-D5 is manufactured under strict quality controls to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity, and structural confirmation. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.