Description

2,2-Dimethyl-3-[2-(Trifluoromethyl)Phenyl]Propanoic Acid is a high-value, synthetically versatile trifluoromethylated organic acid. This compound matters as a critical chiral building block and intermediate in advanced organic synthesis, offering unique steric and electronic properties conferred by its gem-dimethyl and trifluoromethylphenyl groups. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a backbone for creating sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals, where its structure imparts desired thermal and optical properties.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in chemical manufacturing.
• Custom Synthesis Building Block: Utilized in contract research and manufacturing (CRO/CMO) for bespoke synthetic routes requiring complex, fluorinated carboxylic acids.

Basic Information

Product Name	2,2-Dimethyl-3-[2-(Trifluoromethyl)Phenyl]Propanoic Acid
CAS No.	1439900-08-9
Molecular Formula	C₁₂H₁₃F₃O₂
Molecular Weight	246.23 g/mol
Synonyms	α,α-Dimethyl-2-(trifluoromethyl)benzenepropanoic Acid; 2-(Trifluoromethyl)benzeneacetic acid, α,α-dimethyl-; 3-[2-(Trifluoromethyl)phenyl]-2,2-dimethylpropanoic Acid; 2,2-Dimethyl-3-(2-trifluoromethylphenyl)propionic Acid; (RS)-2,2-Dimethyl-3-[2-(trifluoromethyl)phenyl]propanoic Acid; DL-2,2-Dimethyl-3-[2-(trifluoromethyl)phenyl]propanoic Acid; rac-2,2-Dimethyl-3-[2-(trifluoromethyl)phenyl]propanoic Acid
EINECS	Contact for details

Quality Control

Our 2,2-Dimethyl-3-[2-(Trifluoromethyl)Phenyl]Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (enantiomeric excess) or as specified
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.