Description

2-[4-(Carboxymethyl)Phenyl]-2,2-Difluoroacetic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its difluoroacetic acid and carboxymethylphenyl functional groups. This compound is valued for its role in the synthesis of complex molecules, particularly in medicinal chemistry where the introduction of fluorine atoms is critical for modulating bioavailability and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting metabolic and inflammatory diseases.
• Medicinal Chemistry Research: Used in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization, leveraging the fluorine moiety.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides and pesticides with enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions.
• Fluorinated Compound Library: A valuable reagent for constructing diverse fluorinated compound libraries for high-throughput screening.
• Peptide Mimetics: Used in the design and synthesis of peptide analogs with improved stability and binding affinity.

Basic Information

Product Name	2-[4-(Carboxymethyl)Phenyl]-2,2-Difluoroacetic Acid
CAS No.	1436389-36-4
Molecular Formula	C10H8F2O4
Molecular Weight	230.17 g/mol
Synonyms	2-(4-(Carboxymethyl)phenyl)-2,2-difluoroacetic acid; 2-[4-(Carboxymethyl)phenyl]-2,2-difluoroethanoic acid; 4-(Carboxymethyl)-α,α-difluorobenzeneacetic acid; 2,2-Difluoro-2-[4-(carboxymethyl)phenyl]acetic acid; [4-(Carboxymethyl)phenyl]difluoroacetic acid; Difluoro(4-(carboxymethyl)phenyl)acetic acid; CAS 1436389-36-4
EINECS	Contact for details

Quality Control

Our 2-[4-(Carboxymethyl)Phenyl]-2,2-Difluoroacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.