Description

(S)-(((1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yloxy)Methyl)Phosphoryl)Bis(Oxy)Bis(Methylene) Isopropyl Dicarbonate Fumarate is a high-purity, advanced pharmaceutical intermediate with a complex molecular structure designed for targeted therapeutic applications. This compound is critical for research and development in the synthesis of novel nucleoside analogue prodrugs, offering a sophisticated chemical scaffold for medicinal chemistry. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on antiviral and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation antiviral and anticancer prodrug candidates.
• Nucleoside Analogue Research: Used in academic and industrial research to study modified nucleoside structures and their biological activity.
• Prodrug Development: Integral to the design of prodrugs aimed at improving the bioavailability and targeted delivery of active pharmaceutical ingredients (APIs).
• Antiviral Agent Synthesis: A precursor in the development of compounds targeting viral polymerases and replication mechanisms.
• Oncology Therapeutics: Employed in the research and early-stage manufacturing of potential chemotherapeutic agents.
• Bioconjugation & Labeling: The reactive functional groups enable its use in creating labeled compounds for diagnostic or biochemical studies.

Basic Information

Product Name	(S)-(((1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yloxy)Methyl)Phosphoryl)Bis(Oxy)Bis(Methylene) Isopropyl Dicarbonate Fumarate
CAS No.	1432630-26-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Isopropyl (((((2S)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl) bis(methylene) dicarbonate fumarate; GS-441524 monophosphate prodrug intermediate; Remdesivir metabolite prodrug derivative; (S)-GS-441524 MP isopropyl carbonate fumarate; Nucleoside phosphoramidate prodrug precursor; 9-[(2S)-2-[[[[(Isopropoxycarbonyl)oxy]methoxy](hydroxy)phosphoryl]methoxy]propyl]adenine fumarate; ATV006 intermediate; VV116 related compound
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm
Assay	95.0% - 105.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.