Description

Methyl 4-Bromo-3-Chloro-2-Fluorobenzoate is a high-purity, multi-halogenated benzoate ester building block critical for advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated aromatic motifs into their target structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the specific halogen pattern is crucial for bioactivity.
• Ligand and Material Science: Serves as a precursor for synthesizing specialized ligands for catalysis or as a monomer for creating functionalized polymers and advanced materials.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the presence of the bromo substituent.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and constructing complex heterocyclic systems.
• Fluorine Chemistry Studies: Valuable for investigating the influence of an ortho-fluorine atom on reaction kinetics and molecular conformation in aromatic systems.

Basic Information

Product Name	Methyl 4-Bromo-3-Chloro-2-Fluorobenzoate
CAS No.	1427440-57-0
Molecular Formula	C8H5BrClFO2
Molecular Weight	267.48 g/mol
Synonyms	Methyl 4-bromo-3-chloro-2-fluorobenzoate; Benzoic acid, 4-bromo-3-chloro-2-fluoro-, methyl ester; 4-Bromo-3-chloro-2-fluorobenzoic acid methyl ester; Methyl 2-fluoro-4-bromo-3-chlorobenzoate; 2-Fluoro-4-bromo-3-chlorobenzoic acid methyl ester; Methyl 4-bromo-2-fluoro-3-chlorobenzoate; 3-Chloro-4-bromo-2-fluorobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 4-Bromo-3-Chloro-2-Fluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical data are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.