Description

2-(2,4-Difluoro-5-Methyl-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in its role as a versatile intermediate for the Suzuki-Miyaura cross-coupling reaction, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality precursors for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing difluoromethylphenyl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides with enhanced properties.
• Material Science: Serves as a precursor for organic electronic materials, including OLEDs and organic semiconductors.
• Chemical Research: A versatile reagent in academic and industrial R&D labs for palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts.
• Fluorinated Compound Libraries: Integral for creating diverse fluorinated compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	2-(2,4-Difluoro-5-Methyl-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane
CAS No.	1427407-71-3
Molecular Formula	C₁₃H₁₇BF₂O₂
Molecular Weight	254.08 g/mol
Synonyms	2-(2,4-Difluoro-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Methyl-2,4-difluorophenylboronic acid pinacol ester; (2,4-Difluoro-5-methylphenyl)boronic acid pinacol ester; 2,4-Difluoro-5-methylbenzeneboronic acid pinacol ester; 1427407-71-3; Pinacol (2,4-difluoro-5-methylphenyl)boronate
EINECS	Contact for details

Quality Control

Every batch of 2-(2,4-Difluoro-5-Methyl-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is manufactured under strict quality management systems. We ensure compliance with stringent internal specifications, which are designed to meet the exacting requirements of advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee supply reliability and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.