Description

Isopropyl ((R)-((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)(Phenoxy)Phosphoryl)-L-Alaninate is a sophisticated nucleotide analog prodrug, representing a key building block in advanced pharmaceutical research and development. This compound is critical for its role as a precursor in the synthesis of novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, structurally complex intermediates for prodrug development and nucleotide-based drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of nucleotide analog prodrugs for antiviral and anticancer applications.
• Antiviral Drug Development: Used in research and production of therapeutics targeting viruses such as hepatitis B (HBV), hepatitis C (HCV), and other viral pathogens.
• Protease Inhibitor Research: Acts as a key component in the development of protease inhibitors and other enzyme-targeting drugs.
• Biochemical Research: Employed as a tool compound in enzymology and molecular biology studies to investigate nucleotide metabolism and polymerase function.
• Pre-clinical & Clinical Trial Material: Supplied as a high-purity intermediate for the synthesis of Active Pharmaceutical Ingredients (APIs) used in pre-clinical and clinical studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) specializing in complex organic molecules.

Basic Information

Item	Details
Product Name	Isopropyl ((R)-((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)(Phenoxy)Phosphoryl)-L-Alaninate
CAS No.	1422343-76-7
Molecular Formula	C21H27N6O6P
Molecular Weight	490.45 g/mol
Synonyms	Isopropyl (2R)-2-[[[(R)-[[(2R)-1-(6-Aminopurin-9-yl)propan-2-yl]oxy]methyl-phenoxy-phosphoryl]amino]propanoate; GS-7340 Impurity; Tenofovir Alafenamide Related Compound; (R)-PMPA Isopropyl Ester Prodrug Intermediate; Nucleotide Phosphonate Prodrug; Phenoxy Phosphoramidate of L-Alanine Isopropyl Ester; Antiviral Nucleotide Intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality standards suitable for pharmaceutical research and development. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We implement rigorous analytical controls, including HPLC, NMR, and MS, to ensure consistency and traceability. While not a bulk API, our quality system is designed to support its use in critical development pathways, with specifications that can be aligned with client requirements for pre-clinical and clinical-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.