Description

[2-Fluoro-6-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methanol is a high-value boronic ester derivative, a crucial advanced intermediate in modern synthetic organic chemistry. Its primary value lies in its role as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex fluorinated and methoxylated biphenyl scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated aromatic components.
• Material Science Research: Serves as a monomer or precursor for the development of organic electronic materials, such as OLEDs and semiconductors, where its boronic ester group facilitates polymerization or functionalization.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for transition metal catalysis and organocatalysts due to its modifiable methanol and boronate functional groups.
• Chemical Biology Probes: Utilized in the synthesis of fluorescent tags, molecular probes, and bioconjugation reagents for diagnostic and research applications.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	[2-Fluoro-6-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methanol
CAS No.	1417736-84-5
Molecular Formula	C14H20BFO4
Molecular Weight	282.12 g/mol
Synonyms	(4-(Hydroxymethyl)-3-fluoro-5-methoxyphenyl)boronic acid pinacol ester; 2-Fluoro-6-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol; 4-(Hydroxymethyl)-2-fluoro-6-methoxyphenylboronic acid pinacol ester; [2-Fluoro-6-methoxy-4-(pinacolatoboryl)phenyl]methanol; PINACOL [2-FLUORO-6-METHOXY-4-(HYDROXYMETHYL)PHENYL]BORONATE
EINECS	Contact for details

Quality Control

Our [2-Fluoro-6-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.