Description

2,6-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Benzenemethanol is a high-value, multifunctional boronic ester derivative that serves as a critical synthetic intermediate. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and advanced materials chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and organic electronics industries who require the controlled introduction of a difluorinated benzyl alcohol moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates for oncology, CNS disorders, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the difluoro and boronate groups confer specific biological activity and metabolic stability.
• Material Science & OLED Development: Serves as a precursor for creating fluorinated organic semiconductors, liquid crystals, and light-emitting materials for electronic displays.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and tags for imaging and diagnostic applications due to its reactive handles for further functionalization.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form biaryl and conjugated systems with high efficiency and selectivity.
• Custom Synthesis & R&D: A versatile starting material for contract research organizations (CROs) and academic labs exploring new chemical spaces and novel synthetic routes.

Basic Information

Product Name	2,6-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Benzenemethanol
CAS No.	1417736-43-6
Molecular Formula	C13H17BF2O3
Molecular Weight	270.09 g/mol
Synonyms	2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl alcohol; (4-(Hydroxymethyl)-3,5-difluorophenyl)boronic acid pinacol ester; 3,5-Difluoro-4-(hydroxymethyl)phenylboronic acid pinacol ester; 2,6-Difluoro-4-(pinacolatoboryl)benzyl alcohol; Pinacol [4-(hydroxymethyl)-3,5-difluorophenyl]boronate; 1417736-43-6; Benzenemethanol, 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Benzenemethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.