Description

2,4(1H,3H)-Pyrimidinedione, 1-(2-Deoxy-2-Fluoro-α-D-Arabinofuranosyl)-5-Ethyl- is a high-purity nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel antiviral and anticancer therapeutics, where its modified sugar moiety is key to enhancing metabolic stability and target specificity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors working on next-generation nucleoside-based drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of antiviral medications, particularly for targeting viral polymerases.
• Anticancer Drug Research: Used in the discovery and synthesis of experimental chemotherapeutic agents that interfere with DNA replication in cancer cells.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and related biological pathways.
• Process Chemistry & Scale-Up: Serves as a starting material for the GMP-compliant manufacturing of active pharmaceutical ingredients (APIs) in clinical trials.
• Prodrug Synthesis: Utilized to create prodrug forms of nucleoside analogs to improve bioavailability and pharmacokinetic profiles.
• Labeled Compound Preparation: A candidate for isotopic labeling (e.g., with C-13, N-15, or F-18) for use in metabolic tracing and imaging studies.

Basic Information

Product Name	2,4(1H,3H)-Pyrimidinedione, 1-(2-Deoxy-2-Fluoro-α-D-Arabinofuranosyl)-5-Ethyl-
CAS No.	1417190-75-0
Molecular Formula	C11H15FN2O5
Molecular Weight	274.25 g/mol
Synonyms	5-Ethyl-1-(2-deoxy-2-fluoro-α-D-arabinofuranosyl)uracil; 1-(2-Deoxy-2-fluoro-α-D-arabinofuranosyl)-5-ethyluracil; 2'-Deoxy-2'-fluoro-5-ethyl-ara-uridine; 5-Ethyl-2'-fluoro-ara-U; FEAU (2'-F-ara-5-ethyl-U); α-FMAU (5-ethyl variant); 1-(2-Deoxy-2-fluoro-α-D-arabinofuranosyl)-5-ethyl-2,4(1H,3H)-pyrimidinedione
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring traceability and compliance with research and development standards. Our quality commitment supports applications requiring material for GMP starting material evaluation and non-clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.