Description

Gc376 CAS NO 1416992-39-6 is a potent, cell-permeable peptidomimetic inhibitor that specifically targets the main protease (Mpro/3CLpro) of coronaviruses. This compound is critical for antiviral research and development, offering a valuable tool for studying viral replication mechanisms and screening potential therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on virology and infectious disease treatment.

Application

• Antiviral Research: A key biochemical tool for studying the replication cycle of coronaviruses, including SARS-CoV-2.
• Drug Discovery: Used in high-throughput screening assays to identify and evaluate novel antiviral compounds.
• Mechanistic Studies: Enables detailed investigation into the function and inhibition kinetics of the viral 3CL protease.
• Biochemical Assay Development: Serves as a positive control and standard in developing and validating protease activity assays.
• Preclinical Development: Supports in vitro and in vivo studies for potential antiviral therapeutic candidates.

Basic Information

Product Name	Gc376
CAS No.	1416992-39-6
Molecular Formula	C27H40N4O7S
Molecular Weight	564.70 g/mol
Synonyms	GC 376; GC-376; (2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-1-oxo-3-phenylpropyl]amino]-4-methylpentanoyl]amino]-N-[(1S)-3-[benzyl(methyl)amino]-1-[[(1S)-2-hydroxy-1-phenylethyl]amino]-1-oxopropan-2-yl]pentanediamide; N-[(5-Methyl-2-oxo-1,3-dioxol-4-yl)methoxy]carbonyl-L-leucyl-L-phenylalaninal; Mpro inhibitor GC376; 3CLpro inhibitor GC376
EINECS	Contact for details

Quality Control

Our Gc376 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural identity, and stringent controls for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the product should be handled under anhydrous conditions and allowed to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.