Description

Glutathione Disulfide-13C4,15N2 is a stable isotope-labeled analog of oxidized glutathione, a critical biomarker of oxidative stress. This high-purity reference material is essential for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses. It is primarily used by researchers and quality control laboratories in pharmaceutical development, clinical diagnostics, and advanced metabolomics studies.

Application

• Quantitative Mass Spectrometry (MS/MS, LC-MS/MS): Serves as an internal standard for the precise quantification of endogenous glutathione disulfide (GSSG) in biological samples (e.g., plasma, serum, tissue homogenates).
• Biomarker Research: Enables accurate measurement of the GSH/GSSG ratio, a key indicator of cellular redox status and oxidative stress in disease models.
• Pharmaceutical R&D: Used in pharmacokinetic and pharmacodynamic studies to track drug-induced changes in antioxidant systems.
• Clinical Diagnostics: Supports the development and validation of assays for oxidative stress-related disorders.
• Metabolomics & Systems Biology: Facilitates stable isotope dilution analysis for pathway flux studies related to glutathione metabolism.
• Quality Control & Method Validation: Critical for establishing and verifying the accuracy, precision, and linearity of analytical methods in contract research organizations (CROs) and testing labs.

Basic Information

Product Name	Glutathione Disulfide-13C4,15N2
CAS No.	1416898-83-3
Molecular Formula	C2013C4H32N615N2O12S2
Molecular Weight	618.6 g/mol (for labeled form)
Synonyms	GSSG-13C4,15N2; L-Glutathione (oxidized)-13C4,15N2; Oxidized Glutathione-13C4,15N2; (2S)-2-Amino-4-[[(1R)-1-[[(carboxymethyl)amino]-13C]-1-oxo-3-[(sulfanyl-15N)methyl]-3-[[(2S)-2-amino-5-oxo-5-[[(1R)-1-carboxy-2-(13C)carbamoylethyl]amino]pentyl]amino]propyl]amino]-4-oxobutanoic acid; Bis(γ-L-glutamyl-L-cysteinylglycine)-13C4,15N2 disulfide; Isotopically Labeled Glutathione Disulfide
EINECS	Contact for details

Quality Control

Every batch of Glutathione Disulfide-13C4,15N2 is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and identity confirmation via advanced spectroscopic and chromatographic methods. Our quality commitment ensures traceability and reliability for your most demanding research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98%
Isotopic Purity	≥ 99 atom % 13C; ≥ 99 atom % 15N
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.