Description

4,5-Difluoro-2-Methylphenylboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound matters for its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing novel active ingredients and functional molecules. Its specific substitution pattern offers precise control over molecular architecture in target synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system and inflammatory diseases.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Serves as a building block for organic light-emitting diodes (OLEDs), liquid crystals, and other advanced electronic materials.
• Chemical Research & Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Ligand Synthesis: Used to prepare specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Incorporated into polymer backbones to impart specific fluorinated properties.

Basic Information

Product Name	4,5-Difluoro-2-Methylphenylboronic Acid
CAS No.	1416244-48-8
Molecular Formula	C7H7BF2O2
Molecular Weight	171.94 g/mol
Synonyms	(4,5-Difluoro-2-methylphenyl)boronic acid; 2-Methyl-4,5-difluorophenylboronic acid; 4,5-Difluoro-o-tolylboronic acid; Boronic acid, B-(4,5-difluoro-2-methylphenyl)-; 1416244-48-8; 4,5-Difluoro-2-methylbenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-Methylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent industry standards. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment supports applications in cGMP and research environments where reproducibility and purity are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.