Description

(2S)-1-Boc-2-Methylpyrrolidine-2-Methanamine CAS NO 1408057-41-9 is a high-purity, chiral pyrrolidine derivative featuring a Boc-protected amine and a primary amine side chain, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its unique stereochemistry and bifunctional nature make it an essential building block for constructing complex molecules with specific three-dimensional architectures. This compound is primarily required by pharmaceutical R&D and contract manufacturing organizations (CMOs) engaged in the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drugs.
• Peptidomimetic Chemistry: Used to introduce constrained, chiral pyrrolidine scaffolds into peptide backbones to enhance metabolic stability and receptor selectivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Custom Synthesis: A starting material for contract research and manufacturing services (CRAMS) producing bespoke compounds for client projects.

Basic Information

Product Name	(2S)-1-Boc-2-Methylpyrrolidine-2-Methanamine
CAS No.	1408057-41-9
Molecular Formula	C12H24N2O2
Molecular Weight	228.33 g/mol
Synonyms	1-Boc-2-(aminomethyl)-2-methylpyrrolidine, (S)-1-(tert-Butoxycarbonyl)-2-(aminomethyl)-2-methylpyrrolidine; tert-Butyl (2S)-2-(aminomethyl)-2-methylpyrrolidine-1-carboxylate; (S)-2-(Aminomethyl)-2-methylpyrrolidine-1-carboxylic acid tert-butyl ester; (2S)-2-(Aminomethyl)-1-N-Boc-2-methylpyrrolidine; (S)-1-Boc-2-methylpyrrolidine-2-methanamine
EINECS	Contact for details

Quality Control

Our production of (2S)-1-Boc-2-Methylpyrrolidine-2-Methanamine adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high chemical purity. Quality is verified against established specifications using advanced analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.