Description

n-[(8α,9S)-6'-Methoxycinchonan-9-Yl]-4-(Trifluoromethyl)-1,2-Benzenediamine is a sophisticated chiral organic compound derived from the cinchona alkaloid scaffold, valued for its role as a high-performance ligand and catalyst in asymmetric synthesis. Its molecular architecture, featuring a trifluoromethyl-substituted benzenediamine moiety, makes it a critical component for researchers and manufacturers requiring precise stereochemical control. This compound is primarily utilized by the pharmaceutical and fine chemical industries for the development of enantiomerically pure active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Asymmetric Catalysis: Serves as a privileged chiral ligand or organocatalyst in a variety of enantioselective transformations, including hydrogenations, oxidations, and C-C bond-forming reactions.
• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Chiral Resolution Agent: Employed in the separation of racemic mixtures to isolate desired enantiomers with high optical purity.
• Material Science Research: Used in the development of chiral functional materials and sensors due to its inherent chirality and electronic properties.
• Academic & Process R&D: A valuable tool for chemists in university and industrial R&D labs exploring novel synthetic methodologies and reaction mechanisms.
• Agrochemical Synthesis: Potential application in the synthesis of enantiomerically pure agrochemicals, such as herbicides and fungicides, to enhance efficacy and reduce environmental impact.

Basic Information

Product Name	n-[(8α,9S)-6'-Methoxycinchonan-9-Yl]-4-(Trifluoromethyl)-1,2-Benzenediamine
CAS No.	1404088-23-8
Molecular Formula	C27H28F3N3O
Molecular Weight	467.53 g/mol
Synonyms	4-(Trifluoromethyl)-1,2-benzenediamine, N-[(8α,9S)-6'-methoxycinchonan-9-yl]-; (8α,9S)-N-[4-(Trifluoromethyl)-1,2-phenylenediamino]-6'-methoxycinchonan; Cinchona Alkaloid-Diamine Derivative; Chiral Cinchona-Diamine Ligand; Asymmetric Catalyst 1404088-23-8; 1,2-Benzenediamine, 4-(trifluoromethyl)-, N-[(8α,9S)-6'-methoxycinchonan-9-yl]-
EINECS	Contact for details

Quality Control

Our production of n-[(8α,9S)-6'-Methoxycinchonan-9-Yl]-4-(Trifluoromethyl)-1,2-Benzenediamine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive catalytic and synthetic applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas when appropriate to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.