Description

R-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2,2'-Naphthol is a sophisticated chiral ligand and building block of significant importance in advanced organic synthesis and catalysis. Its value lies in its unique sterically hindered, electron-deficient structure, which is highly effective for inducing enantioselectivity in challenging asymmetric transformations. This compound is essential for researchers and process chemists in the pharmaceutical and fine chemical industries developing novel active ingredients and high-value specialty chemicals.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for transition metal-catalyzed reactions, including asymmetric hydrogenation, C-C bond formation, and addition reactions.
• Pharmaceutical Intermediate Synthesis: A key chiral auxiliary or building block in the multi-step synthesis of complex, enantiomerically pure drug candidates and active pharmaceutical ingredients (APIs).
• Material Science Research: Used in the development of chiral functional materials, such as organic light-emitting diodes (OLEDs) and liquid crystals, where its fluorinated aromatic groups can influence electronic properties.
• Methodology Development: Employed in academic and industrial R&D for developing new catalytic systems and testing novel asymmetric synthetic routes.
• Agrochemical Synthesis: Potential application in the synthesis of enantiomerically pure agrochemicals, where specific stereochemistry is crucial for biological activity.

Basic Information

Product Name	R-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2,2'-Naphthol
CAS No.	1402852-05-4
Molecular Formula	C42H26F12O2
Molecular Weight	766.65 g/mol
Synonyms	R-H8-BINOL-C6F5; (R)-3,3'-Bis[3,5-bis(trifluoromethyl)phenyl]-1,1'-bi-2,2'-naphthol (hydrogenated); (R)-5,5',6,6',7,7',8,8'-Octahydro-3,3'-bis[3,5-bis(trifluoromethyl)phenyl]-1,1'-binaphthyl-2,2'-diol; (R)-H8-BINOL-3,3'-di(3,5-bis(trifluoromethyl)phenyl); R-Octahydro-BINOL-C6F5 Derivative; Chiral Fluorinated BINOL Ligand; Asymmetric Catalyst Ligand 1402852-05-4.
EINECS	Contact for details

Quality Control

Our production of R-3,3'-Bis(3,5-Bis(Trifluoromethyl)Phenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2,2'-Naphthol adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for catalytic performance. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess (ee), and impurity profile is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.