Description

3-Chloro-2-(Trifluoromethyl)Phenylboronic Acid is a specialized organoboron building block, a key intermediate in modern synthetic chemistry. Its value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, particularly in the development of compounds with trifluoromethyl and chloro substituents for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the specific halogenated aromatic structure contributes to product efficacy.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form biaryl and other carbon-carbon bonds with high selectivity.
• Chemical Library Development: Utilized in combinatorial chemistry and high-throughput screening for the discovery of new chemical entities.
• Ligand and Catalyst Preparation: Acts as a starting material for synthesizing specialized ligands and catalysts used in asymmetric synthesis.

Basic Information

Product Name	3-Chloro-2-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1401990-62-2
Molecular Formula	C7H5BClF3O2
Molecular Weight	223.38 g/mol
Synonyms	(3-Chloro-2-(trifluoromethyl)phenyl)boronic acid; 2-Chloro-α,α,α-trifluoro-m-tolylboronic acid; 3-Chloro-2-trifluoromethylbenzeneboronic acid; Boronic acid, B-[3-chloro-2-(trifluoromethyl)phenyl]-; 3-Chloro-α,α,α-trifluoro-o-tolylboronic acid; 2-(Trifluoromethyl)-3-chlorophenylboronic Acid
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-(Trifluoromethyl)Phenylboronic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.