Description

2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethyl)Benzoic Acid is a high-value, multifunctional chemical building block that combines a protected boronic ester with a benzoic acid moiety. This compound is critical for enabling complex organic synthesis, particularly in the development of advanced materials and active pharmaceutical ingredients (APIs). It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for applications in cross-coupling reactions and molecular scaffold construction.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel drug candidates, especially those containing trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the boronic ester functionality allows for efficient carbon-carbon bond formation to create complex molecular architectures.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs or organic photovoltaics, due to its conjugated system and functional handles.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological processes, leveraging the reactivity of the boronic ester for bioconjugation strategies.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry laboratories focused on new catalytic processes or boron chemistry.
• Custom Synthesis & Scale-up: Supplied to custom synthesis organizations (CSOs) and CDMOs for process development and pilot-scale production of target molecules.

Basic Information

Product Name	2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethyl)Benzoic Acid
CAS No.	1400976-18-2
Molecular Formula	C14H16BF3O4
Molecular Weight	316.09 g/mol
Synonyms	4-(Trifluoromethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzoic acid; Pinacol 2-Carboxy-5-(trifluoromethyl)phenylboronate; 2-Borono-4-(trifluoromethyl)benzoic acid, pinacol ester; (2-Carboxy-5-(trifluoromethyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, impurities, and other critical parameters are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.