Description

1-(Piperazine-13C4)Carboxylic Acid tert-B is a stable isotope-labeled derivative of a key piperazine carboxylic acid building block, where four carbon atoms are replaced with the 13C isotope. This compound is essential for applications requiring high sensitivity and specificity in quantitative analysis, serving as a critical internal standard or tracer. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors for advanced mass spectrometry (MS) and nuclear magnetic resonance (NMR) studies.

Application

• As a stable isotope-labeled internal standard for the precise quantification of piperazine-based active pharmaceutical ingredients (APIs) and metabolites using LC-MS/MS.
• In pharmacokinetic and metabolic pathway studies to trace drug absorption, distribution, metabolism, and excretion (ADME) with high accuracy.
• For the synthesis of isotope-labeled complex molecules in medicinal chemistry research and development.
• As a key reagent in proteomics and biomarker discovery workflows that rely on isotope dilution mass spectrometry.
• In environmental fate studies of agrochemicals to understand degradation pathways and metabolite formation.
• For NMR spectroscopy as a tool to elucidate molecular structure and dynamics without signal interference from natural abundance carbon.

Basic Information

Product Name	1-(Piperazine-13C4)Carboxylic Acid tert-B
CAS No.	1391054-31-1
Molecular Formula	C513C4H18N2O2
Molecular Weight	~206.20 g/mol (for 13C4 labeled form)
Synonyms	tert-Butyl 1-piperazinecarboxylate-13C4; 1-Boc-piperazine-13C4; 1-(tert-Butoxycarbonyl)piperazine-13C4; N-Boc-piperazine-13C4; Piperazine-1-carboxylic acid tert-butyl ester-13C4; 1-Piperazinecarboxylic acid, 1,1-dimethylethyl ester-13C4; Boc-Piperazine-13C4; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our isotope-labeled building blocks are produced and tested under strict quality control protocols to ensure exceptional chemical and isotopic purity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm isotopic enrichment and chemical identity. Certificates of Analysis (COA) detailing purity, isotopic abundance, and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom % 13C
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.