Description

4-Chloro Kynurenine-13C2,15N is a stable isotope-labeled analog of the endogenous tryptophan metabolite, 4-chlorokynurenine. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, enabling highly accurate and precise measurement of its endogenous counterpart in complex biological matrices. It is an essential tool for researchers and analytical laboratories in the fields of neuropharmacology, metabolomics, and biomarker discovery, where understanding kynurenine pathway dynamics is critical.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the absolute quantification of endogenous 4-chlorokynurenine in plasma, serum, cerebrospinal fluid, and tissue homogenates.
• Metabolomics Research: Used in tracer studies to investigate the kynurenine pathway's role in neurological disorders, immune response, and cancer metabolism.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking and quantification of drug metabolites related to the tryptophan degradation pathway in preclinical and clinical studies.
• Biomarker Assay Development: Facilitates the development and validation of robust clinical diagnostic assays targeting tryptophan metabolites.
• Quality Control in Reference Material Production: Acts as a calibrant or reference compound in the preparation of certified reference materials (CRMs) for clinical laboratories.

Basic Information

Product Name	4-Chloro Kynurenine-13C2,15N
CAS No.	1391051-72-1
Molecular Formula	C913C2H11Cl15N2O3
Molecular Weight	Contact for details
Synonyms	4-Chloro-DL-kynurenine-13C2,15N; (RS)-2-Amino-4-(2-chlorophenyl)-4-oxobutanoic-13C2,15N acid; 4-Chlorokynurenine-13C2,15N; 4-Cl-KYN-13C2,15N; 2-Amino-4-(2-chlorobenzoyl)butanoic-13C2,15N acid; 4-Chloro-L-kynurenine-13C2,15N (if applicable); Stable Isotope Labeled 4-Chlorokynurenine
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro Kynurenine-13C2,15N is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure high isotopic purity and chemical purity essential for analytical applications. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity confirmation are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Isotopic Purity	≥99 atom % 13C; ≥99 atom % 15N
Chemical Purity	≥95%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.