Description

n-[Des-(2-Isopropyl-Thiazol-4-Yl)-1.3-Dioxo-2-(Methylaza)-Propyl] Cobicistat Hydrochloride is a high-purity pharmaceutical intermediate and reference standard, specifically a derivative of the pharmacokinetic enhancer Cobicistat. This compound is critical for research and development in antiviral drug discovery, particularly for HIV and related viral infections. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in process development, impurity profiling, and quality control of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis and process development of Cobicistat and related antiviral compounds.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing in API manufacturing.
• Impurity Profiling: Employed in the identification and quantification of process-related impurities and degradation products in Cobicistat API batches.
• Drug Discovery Research: Acts as a structural analog in medicinal chemistry programs aimed at developing new pharmacokinetic enhancers or protease inhibitors.
• Regulatory Submissions: Provides essential data and materials for regulatory filings (e.g., with FDA, EMA) to demonstrate understanding and control of the manufacturing process.
• Academic & Clinical Research: Supports non-clinical studies investigating drug metabolism, pharmacokinetics (DMPK), and drug-drug interactions.

Basic Information

Product Name	n-[Des-(2-Isopropyl-Thiazol-4-Yl)-1.3-Dioxo-2-(Methylaza)-Propyl] Cobicistat Hydrochloride
CAS No.	1383570-51-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cobicistat Des-Thiazole Derivative; Cobicistat Impurity; Cobicistat Related Compound; 1,3-Dioxo-2-(methylaza)-propyl cobicistat derivative; GS-9350 Derivative; Tybost Intermediate; Pharmacokinetic Enhancer Intermediate; (1R,2R,4S)-N-[(2S,3R,4R,5S)-4-[(2-Isopropylthiazol-4-yl)methyl]-3,5-dimethylpiperazin-2-yl]-2-hydroxy-4-[4-methoxy-1H-pyrrolo[2,3-c]pyridin-1-yl]cyclopentyl]methanesulfonamide Derivative Hydrochloride
EINECS	Contact for details

Quality Control

Our n-[Des-(2-Isopropyl-Thiazol-4-Yl)-1.3-Dioxo-2-(Methylaza)-Propyl] Cobicistat Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.