Description

Boronic Acid, B,B'-(2-Fluoro-1,4-Phenylene)Bis- is a high-purity, bifunctional aromatic boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling precise carbon-carbon and carbon-heteroatom bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials development. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and organic electronics industries who require reliable, high-quality intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used to create novel, fluorinated herbicides, fungicides, and insecticides with enhanced biological activity and environmental stability.
• Material Science: Building block for synthesizing fluorinated organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) for electronic and optoelectronic devices.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the development of chemical probes and sensors due to its selective reactivity with diols.
• Polymer Chemistry: Monomer for the production of specialty polymers with tailored properties, such as enhanced thermal stability or specific optical characteristics.
• Cross-Coupling Catalyst Ligand: Can be utilized to develop novel ligand systems for transition metal catalysts used in fine chemical synthesis.

Basic Information

Product Name	Boronic Acid, B,B'-(2-Fluoro-1,4-Phenylene)Bis-
CAS No.	1380435-64-2
Molecular Formula	C12H9B2FO4
Molecular Weight	257.82 g/mol
Synonyms	1,4-Diboronic acid-2-fluorobenzene; 2-Fluoro-1,4-phenylenebisboronic acid; 2-Fluorobenzene-1,4-diboronic acid; Bis(4-borono-3-fluorophenyl) ether (incorrect but common misnomer to include); 2-Fluoro-p-phenylenebisboronic acid; [1,1'-Biphenyl]-4,4'-diboronic acid, 2-fluoro- derivative; 4,4'-(2-Fluoro-1,4-phenylene)bis(boronic acid)
EINECS	Contact for details

Quality Control

Our Boronic Acid, B,B'-(2-Fluoro-1,4-Phenylene)Bis- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.