Description

2,2-Difluorocyclopentane-1-Carboxylic Acid is a high-purity fluorinated carboxylic acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in the unique reactivity and stereochemistry imparted by the difluorocyclopentane scaffold, which is essential for modulating the physical and biological properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, where the fluorinated cyclopentane ring can enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced materials with tailored surface properties and chemical resistance.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2,2-Difluorocyclopentane-1-Carboxylic Acid
CAS No.	1378525-26-8
Molecular Formula	C6H8F2O2
Molecular Weight	150.12 g/mol
Synonyms	2,2-Difluorocyclopentanecarboxylic Acid; Cyclopentanecarboxylic acid, 2,2-difluoro-; 2,2-Difluoro-1-cyclopentanecarboxylic acid; 1-Carboxy-2,2-difluorocyclopentane; Difluorocyclopentanecarboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluorocyclopentane-1-Carboxylic Acid is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemicals and advanced intermediates. Comprehensive analytical testing, including chiral purity assessment, is performed. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.