Description

Velpatasvir is a high-purity, direct-acting antiviral agent (DAA) belonging to the NS5A inhibitor class. It is a critical active pharmaceutical ingredient (API) used in combination therapies for the treatment of chronic hepatitis C virus (HCV) infection. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing next-generation antiviral medications. Its high selectivity and potency make it a cornerstone in modern HCV treatment regimens targeting multiple genotypes.

Application

• Pharmaceutical API: Primary use as the active ingredient in fixed-dose combination tablets (e.g., with Sofosbuvir) for HCV treatment.
• Antiviral Drug Formulation: Formulation into various dosage forms, including oral tablets, for commercial pharmaceutical products.
• Clinical Research: Utilization in preclinical and clinical studies for investigating new HCV treatment protocols and combination therapies.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in QC laboratories.
• Process Development: Used in chemical process R&D for scale-up, optimization, and synthesis of novel antiviral analogs.
• Regulatory Submissions: Sourced for generating data required for drug master files (DMF), ANDAs, and other regulatory compliance dossiers.

Basic Information

Product Name	Velpatasvir
CAS No.	1377049-84-7
Molecular Formula	C49H54N8O8
Molecular Weight	883.00 g/mol
Synonyms	VELPATASVIR; GS-5816; (2R,5S,13aR)-N-(4-Fluorophenyl)methyl-8-methoxy-7-(9-methoxy-8-(2-methoxyethoxy)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2',3':6,7]naphtho[1,2-d]imidazol-5-yl)-2,5-dimethyl-3,6,9,12,15-pentaoxo-1,2,3,4,5,6,9,12,15,13a-decahydropyrrolo[1',2':1,2]pyrido[3,4-b]indol-13-carboxamide; Epclusa component (with Sofosbuvir)
EINECS	Contact for details

Quality Control

Our Velpatasvir is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identification by spectroscopic methods. We support regulatory compliance, and a detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and meet the stringent requirements of pharmaceutical manufacturers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and potency. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.