Description

Elbasvir is a direct-acting antiviral agent belonging to the NS5A inhibitor class, specifically designed for the treatment of chronic hepatitis C virus (HCV) infection. Its primary value lies in its high potency and specificity against certain HCV genotypes, offering a critical component in modern, interferon-free combination therapies. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers and research institutions developing and producing antiviral medications, particularly for genotype 1 and 4 infections. Consistent quality and reliable supply are paramount for ensuring the efficacy and safety of the final drug product.

Application

• Pharmaceutical API: Primary use as the active ingredient in fixed-dose combination tablets for treating chronic Hepatitis C.
• Antiviral Drug Formulation: Formulation into oral solid dosage forms (e.g., tablets) in combination with other antivirals like grazoprevir.
• Clinical Research: Utilization in preclinical and clinical studies for investigating new HCV treatment regimens and combination therapies.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in pharmaceutical labs.
• Process Development: Used in chemical process research and development (R&D) for optimizing synthesis and scale-up pathways.
• Generic Drug Manufacturing: Sourcing for the production of generic versions of approved elbasvir-containing medications post-patent expiry.

Basic Information

Product Name	Elbasvir
CAS No.	1370468-36-2
Molecular Formula	C49H55N9O7
Molecular Weight	882.02 g/mol
Synonyms	MK-8742; Elbasvir (USAN); (6aR,10aR)-6a,7,10,10a-Tetrahydro-6H-benzo[c]chromen-3-ol; 1H-Imidazo[1,2-a]pyrrolo[2,3-c]pyridin-3-ol; NS5A inhibitor MK-8742; Grazoprevir/Elbasvir combination component
EINECS	Contact for details

Quality Control

Our Elbasvir is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical application. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling using techniques such as HPLC and NMR. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.