Description

Ahu-377 (Hemicalcium Salt) is a high-purity pharmaceutical intermediate, specifically the hemicalcium salt form of the active moiety. This compound is critical for ensuring precise formulation and optimal bioavailability in final drug products. It is primarily required by pharmaceutical R&D and manufacturing sectors for the development and production of cardiovascular and metabolic disease therapies.

Application

• Key intermediate in the synthesis of sacubitril, a component of the combination drug Entresto® (sacubitril/valsartan).
• Critical raw material for the production of angiotensin receptor-neprilysin inhibitor (ARNI) class pharmaceuticals.
• Used in cardiovascular disease research and drug development programs.
• Essential for process development and scale-up activities in API (Active Pharmaceutical Ingredient) manufacturing.
• Reference standard for analytical method development and quality control testing.
• Building block for related metabolic disorder therapeutic candidates.

Basic Information

Product Name	Ahu-377 (Hemicalcium Salt)
CAS No.	1369773-39-6
Molecular Formula	C24H25CaN2O5 • xH2O
Molecular Weight	Contact for details
Synonyms	AHU-377 hemicalcium salt; Sacubitril calcium salt; LCZ696 intermediate; (2R,4S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid hemicalcium salt; Entresto intermediate; ARNI intermediate; LBQ657 calcium salt; Neprilysin inhibitor intermediate
EINECS	Contact for details

Quality Control

Our Ahu-377 (Hemicalcium Salt) is manufactured under strict quality systems suitable for pharmaceutical use. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and conformity to stringent specifications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific GMP, ICH Q7, or customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Water Content (KF)	≤5.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.