Description

2-Amino-9-((1R,3S,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)-1,9-Dihydro-6H-Purin-6-One is a high-purity nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel antiviral and anticancer therapeutics, particularly in the development of nucleotide-based prodrugs. It is essential for medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries seeking to develop next-generation treatments.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of nucleotide analogs and prodrugs targeting viral infections.
• Antiviral Drug Research: Critical precursor in the R&D of novel therapeutics for hepatitis B (HBV), hepatitis C (HCV), and other viral diseases.
• Oncology Research: Used in the development of anticancer agents that target cellular replication mechanisms.
• Process Chemistry: Serves as a starting material or advanced intermediate in scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing processes.
• Biochemical Research: Utilized in enzymatic studies and as a substrate analog to investigate nucleotide metabolism pathways.
• Custom Synthesis: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific novel chemical entities.

Basic Information

Item	Detail
Product Name	2-Amino-9-((1R,3S,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)-1,9-Dihydro-6H-Purin-6-One
CAS No.	1367369-81-0
Molecular Formula	C12H15N5O3
Molecular Weight	277.28 g/mol
Synonyms	2-Amino-9-[(1R,3S,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-6,9-dihydro-1H-purin-6-one; (1'R,2'S,3'R)-Isomer of 9-(2,3-Dihydroxy-4-methylenecyclopentyl)guanine; Cyclopentyl Guanine Analog; Nucleoside Analog Intermediate; 2-Amino-9-(4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl)-1,9-dihydro-6H-purin-6-one; Guanine Cyclopentyl Derivative; Antiviral Nucleoside Precursor
EINECS	Contact for details

Quality Control

Our 2-Amino-9-((1R,3S,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)-1,9-Dihydro-6H-Purin-6-One is manufactured under strict quality systems suitable for pharmaceutical R&D. All batches undergo rigorous analytical testing, including HPLC for purity and chiral purity, to ensure compliance with stringent specifications. A comprehensive Certificate of Analysis (COA) detailing identity, assay, impurity profile, and residual solvents is provided with each shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.