Description

(1R,3R,4R)-Entecavir is a high-purity, stereochemically defined pharmaceutical intermediate and active pharmaceutical ingredient (API). This compound is a critical chiral building block in the synthesis of Entecavir, a potent nucleoside analog used as an antiviral medication. It is essential for pharmaceutical manufacturers and advanced research institutions engaged in developing and producing antiviral therapies, particularly for the treatment of chronic hepatitis B virus (HBV) infection.

Application

• Pharmaceutical API Synthesis: Primary use as a key chiral intermediate in the industrial-scale production of Entecavir monohydrate, the active ingredient in antiviral drugs.
• Antiviral Drug Development: Serves as a crucial starting material or reference standard in R&D for novel nucleoside analog therapeutics targeting viral polymerases.
• Process Chemistry & Optimization: Used by process chemists to develop and scale up efficient, stereoselective synthetic routes for Entecavir.
• Analytical Reference Standard: Employed as a high-purity standard in quality control laboratories for HPLC, chiral analysis, and method validation to ensure drug product purity and identity.
• Academic & Contract Research: Utilized in university and CRO settings for mechanistic studies and biological evaluation of antiviral compounds.
• Generic Drug Manufacturing: A vital raw material for manufacturers producing generic versions of Entecavir-based medications, ensuring bioequivalence.

Basic Information

Product Name	(1R,3R,4R)-Entecavir
CAS No.	1367369-76-3
Molecular Formula	C12H15N5O3
Molecular Weight	277.28 g/mol
Synonyms	BMS-200475-09; (1R,3R,4R)-2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one; (1R,3R,4R)-Entecavir Intermediate; Entecavir (1R,3R,4R)-Isomer; (-)-Entecavir Enantiomer; NSC 768467; SQ 34676; Antiviral Nucleoside Intermediate
EINECS	Contact for details

Quality Control

Our (1R,3R,4R)-Entecavir is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for pharmaceutical use. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. Our quality commitment aligns with cGMP principles for API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.