Description

Glecaprevir is a potent, direct-acting antiviral agent belonging to the NS3/4A protease inhibitor class. It is a critical active pharmaceutical ingredient (API) used in combination therapies for the treatment of chronic hepatitis C virus (HCV) infection. This high-purity compound is essential for pharmaceutical manufacturers and research institutions developing next-generation antiviral medications. Its targeted mechanism offers a high barrier to resistance, making it a cornerstone in modern HCV treatment regimens.

Application

• Pharmaceutical API: Primary use as the active ingredient in fixed-dose combination antiviral tablets for Hepatitis C treatment.
• Combination Therapy: Used in conjunction with pibrentasvir (e.g., in Mavyret®/Maviret®) to treat multiple HCV genotypes.
• Drug Substance Manufacturing: Serves as the key chemical entity for formulation into final dosage forms (tablets).
• Clinical Research: Utilized in preclinical and clinical studies for investigating new HCV treatment protocols and combination strategies.
• Reference Standard: Serves as an analytical standard for quality control and assay development in pharmaceutical laboratories.
• Process Development: Used in R&D for optimizing synthetic routes and scale-up processes for commercial manufacturing.

Basic Information

Product Name	Glecaprevir
CAS No.	1365970-03-1
Molecular Formula	C38H46F4N5O9S
Molecular Weight	824.86 g/mol
Synonyms	ABT-493; Glecaprevirum; (1R,18R,20R,24S,27S)-N-[(1S)-1-Cyclopropyl-2-[(2S)-2-[[(1S,4R,6S,14S,18R)-14-tert-Butoxycarbonylamino-18-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl]-15,15-dimethyl-3,16-dioxo-2,17-dioxa-4,15-diazatricyclo[14.3.0.04,6]nonadec-7-en-8-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]-20,24-bis(trifluoromethyl)-10-thia-3,7,23,26-tetraazapentacyclo[24.2.1.04,9.05,8.013,18]nonacosa-4(9),5,7,13-tetraene-2,8,22,25-tetrone; A-1282583; GLE
EINECS	Contact for details

Quality Control

Our Glecaprevir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) documenting compliance with relevant specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.