Description

Sacubitril is a potent and selective neprilysin inhibitor, a key active pharmaceutical ingredient (API) in combination therapies for cardiovascular conditions. Its primary commercial and therapeutic significance lies in its role in the blockbuster medication used to treat chronic heart failure. This high-purity intermediate is essential for pharmaceutical manufacturers and advanced research institutions developing next-generation cardiovascular treatments.

Application

• Pharmaceutical API Synthesis: Primary use as the neprilysin inhibitor component in the synthesis of Sacubitril/Valsartan combination drug products.
• Cardiovascular Drug Development: Critical raw material for R&D focused on heart failure medications and other conditions where neprilysin inhibition is beneficial.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in pharmaceutical laboratories.
• Clinical Research: Used in the formulation of investigational new drugs (INDs) for clinical trials targeting cardiovascular and renal diseases.
• Process Chemistry & Scale-Up: Employed in process optimization and scale-up activities for commercial pharmaceutical manufacturing.

Basic Information

Item	Details
Product Name	Sacubitril
CAS No.	1361408-17-4
Molecular Formula	C24H29NO5
Molecular Weight	411.49 g/mol
Synonyms	AHU-377; (2R,4S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester; N-[(2S,4R)-1-(1,1'-Biphenyl]-4-ylmethyl)-5-ethoxy-4-methyl-5-oxopentan-2-yl]-4-methylpentanamide; LCZ696 Sacubitril component; Entresto component; Sacubitrilum
EINECS	Contact for details

Quality Control

Our Sacubitril CAS NO 1361408-17-4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, identification by IR and NMR, and stringent control of residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) compliant with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.10%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.