Description

(3Ar,8Ar)-(-)-4,4,8,8-Tetrakis (3,5-Di-I-Propylphenyl)Tetrahydro-2,2-Dimethyl-6-Phenyl-1,3-Dioxolo[4,5-E]Dioxaphosphepin is a sophisticated chiral phosphine-oxazoline hybrid ligand, a key building block in asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, crucial for producing single-isomer pharmaceutical intermediates and fine chemicals with superior purity and yield. This advanced ligand is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control in metal-catalyzed reactions such as hydrogenations, cross-couplings, and hydrosilylations.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amino acids and pharmaceutical building blocks.
• Critical component in asymmetric cross-coupling and C-H activation reactions to construct complex chiral molecules.
• Use in enantioselective hydrosilylation processes for the production of chiral alcohols and silanes.
• Catalyst development for asymmetric synthesis in academic and industrial R&D laboratories.
• Production of high-value active pharmaceutical ingredients (APIs) and advanced intermediates requiring strict stereochemical fidelity.
• Manufacture of agrochemicals and flavors & fragrances where enantiopurity impacts biological activity or sensory profile.

Basic Information

Item	Detail
Product Name	(3Ar,8Ar)-(-)-4,4,8,8-Tetrakis (3,5-Di-I-Propylphenyl)Tetrahydro-2,2-Dimethyl-6-Phenyl-1,3-Dioxolo[4,5-E]Dioxaphosphepin
CAS No.	1361146-90-8
Molecular Formula	C58H72IO4P
Molecular Weight	1014.98 g/mol
Synonyms	(-)-DTBM-SEGPHOS; (R)-DTBM-SEGPHOS; (R)-(-)-4,4'-Bi-1,3-benzodioxole-5,5'-diylbis(di-3,5-di-tert-butylphenylphosphine); DTBM-SEGPHOS ligand; 5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; SEGPHOS derivative; Chiral diphosphine ligand; Asymmetric hydrogenation ligand.
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management protocols to ensure exceptional purity and enantiomeric excess (ee) for reliable catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as chemical purity (by HPLC/NMR), enantiomeric purity, and specific rotation. Our production adheres to cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain long-term stability and prevent oxidation or degradation of the phosphine moiety. The compound is moisture-sensitive; handle and store in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (ee)	≥ 99.0%
Specific Rotation [α]D20	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.