Description

n-Acetyl-S-(2-Cyanocarboxyethyl)-L-Cysteine-D3 Bis(Dicyclohexylamine) Salt is a high-purity, deuterated internal standard critical for advanced analytical chemistry. This compound is specifically designed for the accurate quantification of related metabolites in complex biological matrices, ensuring superior precision and reliability in sensitive assays. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, contract research organization (CRO), and clinical diagnostics sectors, where method validation and regulatory compliance are paramount.

Application

• LC-MS/MS Internal Standard: Primary use as a stable isotope-labeled internal standard for the precise quantification of acrylamide or related thioether metabolite adducts in biomonitoring studies.
• Biomarker Research & Validation: Enables accurate measurement of exposure biomarkers in human urine or blood plasma for occupational health and toxicological research.
• Pharmaceutical Metabolism Studies: Used in pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies to track drug-derived cysteine adducts.
• Food Safety & Environmental Analysis: Supports method development for detecting acrylamide-derived mercapturic acid metabolites as indicators of dietary or environmental exposure.
• Reference Standard for GLP/GMP Compliance: Serves as a certified reference material in regulated laboratories to ensure data integrity for FDA, EMA, and other agency submissions.
• Proteomics & Redox Biology: Aids in the study of protein S-alkylation and oxidative stress markers through targeted mass spectrometry workflows.

Basic Information

Item	Details
Product Name	n-Acetyl-S-(2-Cyanocarboxyethyl)-L-Cysteine-D3 Bis(Dicyclohexylamine) Salt
CAS No.	1356848-13-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-Acetyl-S-(2-cyano-2-carboxyethyl)-L-cysteine-d3 dicyclohexylamine salt; N-Acetyl-S-(carboxyethyl-cyano)-L-cysteine-d3 bis-DCHA salt; AAMA-d3 DCHA Salt; N-Acetyl-S-(2-cyano-2-carboxyethyl)cysteine-d3 bis(dicyclohexylammonium) salt; Deuterated Acrylamide Mercapturic Acid (AAMA) Internal Standard; 2-Cyano-2-[(1R)-1-[(2R)-2-(acetylamino)-3-carboxypropyldisulfanyl]ethyl]acetic-3,3,3-d3 acid bis(dicyclohexylamine) salt
EINECS	Contact for details

Quality Control

Every batch of our n-Acetyl-S-(2-Cyanocarboxyethyl)-L-Cysteine-D3 Bis(Dicyclohexylamine) Salt is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet the exacting standards for mass spectrometry. We provide comprehensive Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, isotopic purity (D-enrichment), and mass spectrometry data. Our quality commitment supports compliance with GLP and ISO 17025 guidelines for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.